- 产品详情
- 产品参数
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FGF-basic (146aa), Human Fibroblast Growth Factor-basic FGF-2 BFGF FGFB HBGF-2 bFGF Prostatropi FGF 2 FGF2 Fibroblast Growth Factor 2 Basic Fibroblast Growth Factor bFGF Heparin-Binding Growth Factor 2 HBGF-2
Product Description:
Species | Human |
Protein Construction | FGF-basic (Pro143-Ser288) |
Accession # P09038 | |
Purity | > 95% as analyzed by SDS-PAGE |
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method |
Biological Activity | ED50 < 0.25 ng/ml, measured by the cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 4.0 × 106 units/mg |
Expression System | E. coli |
Apparent Molecular Weight | ~16.4 kDa, on SDS-PAGE under reducing conditions. |
Formulation | Lyophilized after extensive dialysis against PBS. |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 50 μg/ml. |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background:
| Target Background | Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomycotes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury. |
| Synonyms | Fibroblast Growth Factor-basic; FGF-2; BFGF; FGFB; HBGF-2; bFGF; Prostatropin |
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