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Phenylacetyl Coenzyme A, Phenylacetyl CoA
Description: | Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica[1]. |
Molecular Weight: | 885.67 |
Formula: | C29H42N7O17P3S |
CAS No.: | 7532-39-0 |
| Purity: | ＞98% |
Solubility: | Soluble in DMSO; PBS (pH 7.2): 10 mg/ml |
Storage: | Store at -20°C |
Background:
Phenylacetyl coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source[1]. It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes[2].
References:
1.Miñambres, B., Martínex-Blanco, H., Olivera, E.R., et al. Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenum. J. Biol. Chem. 271(52), 33531-33538 (1996).
2. Sakamoto, K., Agari, Y., Kuramitsu, S., et al. Phenylacetyl coenzyme A is an effector molecule of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB8. J. Bacteriol. 193(17), 4388-4395 (2011).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.