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Endo S2 Endo-β-N-acetylglucosaminidase S2 Recombinant Endo-beta-N-acetylglucosaminidase
Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection, thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway. Endo S2 recognizes the conserved N-glycans on the Fc region of IgG by hydrolyzing the chitobiose core (at the beta -1,4 linkage between the two N-acetylglucosamines) of the N-glycans.
| Alternate Names: | Endo-beta-N-acetylglucosaminidase EndoS2, Endo-S2, Endo S2 |
Species: | Streptococcus pyogenes |
Source: | Expressed in E. coli |
Buffer: | 20mMTris-HCl, pH 7.5，200mM NaCl,10% glycerol |
Purity: | >90 % as determined by SDS-PAGE |
Molecular weight： | 92kDa |
Enzyme activity： | ≥20000U/ml |
Storage & Stability: | Upon receipt, store at -20°C to -80°C. Store aliquots of the stock solution at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
Unit Definition | One unit is defined as the amount of enzyme required to remove >95% of the carbohydrate from 5 μg of human IgG in 1 hour at 37ºC in a total reaction volume of 10 µl |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.