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EPZ015938 EPZ-015938 GSK3326595 1616392-22-3
GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.
| Cas No. | 1616392-22-3 |
| Synonyms | EPZ015938 |
| Canonical SMILES | O=C(C)N1CCC(NC2=NC=NC(C(NC[C@H](O)CN3CCC(C=CC=C4)=C4C3)=O)=C2)CC1 |
| Formula | C24H32N6O3 |
| Solubility | DMSO : ≥ 30 mg/mL (66.29 mM) |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. |
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
| M.Wt | 452.55 |
| Storage | Store at -20°C |
GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin's lymphoma[1].
References:
[1]. WO 2016022605 A1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.