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GBT-440 Voxelotor 1446321-46-5
Voxelotor (GBT 440) is an orally bioavailable modulator of sickle cell hemoglobin.
| Cas No. | 1446321-46-5 |
| Synonyms | Voxelotor |
| Canonical SMILES | OC1=CC=CC(OCC2=C(C3=CC=NN3C(C)C)N=CC=C2)=C1C=O |
| Formula | C19H19N3O3 |
| M.Wt | 337.37 |
| Storage | Store at -20°C |
| Solubility | DMSO : ≥ 125 mg/mL (370.51 mM) |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. |
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
References:
[1]. Metcalf B, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.