$ 80.00+
GNE-3511 dual leucine zipper kinase (DLK) inhibitor 1496581-76-0
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1496581-76-0 GNE-3511.png



GNE-3511 dual leucine zipper kinase (DLK) inhibitor 1496581-76-0


GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.


Cas No.

1496581-76-0

Canonical SMILES

N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1

Formula

C23H26F2N6O

M.Wt

440.49

Solubility

DMSO : ≥ 32 mg/mL (72.65 mM)

Storage

Store at -20°C

General tips

Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.

 

To increase solubility, heat the   tube to 37°C and then oscillate in an ultrasonic bath for some time.

Shipping Condition

Evaluation sample solution:   shipped with blue ice. All other sizes available: with RT, or with Blue Ice   upon request.


References:

[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18.



For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.


Brand
DiLab
Cat NO.
DL-12947
Cas NO.
1496581-76-0
Formula
C23H26F2N6O
MW
440.49
Purity
> 99%
Price
$80.00
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