- Detail
- Parameters
- Review
MS023 dihydrochloride 1992047-64-9
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]
| Cas No. | 1992047-64-9 | ||
| Canonical SMILES | CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl | ||
| Formula | C17H27Cl2N3O | M.Wt | 360.32 |
| Solubility | DMSO: ≥ 150 mg/mL (416.30 mM) | Storage | Store at -20°C |
MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1]. MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1]. Western Blot Analysis[1] Cell Line: MCF7 and HEK293 cells
[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.