
EPZ015666 GSK3235025 1616391-65-1 EPZ015666 1616391-65-1
Biological Activity
EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models.
Chemical Information
| Molecular Weight | 383.44 |
Formula | C20H25N5O3 |
CAS Number | 1616391-65-1 |
Solubility (25°C) | DMSO 60 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years |
In solvent -80°C 6 months ; -20°C 1 month |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.