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Liproxstatin-1 950455-15-9
Biological Activity
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.
Chemical Information
| Molecular Weight | 340.85 |
Formula | C19H21ClN4 |
CAS Number | 950455-15-9 |
Solubility (25°C) | DMSO ≥ 10 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years |
In solvent -80°C 6 months ; -20°C 1 month |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.