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Emapunil AC-5216 XBD-173 226954-04-7
Biological Activity
AC 5216 is a ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.
Chemical Information
| Molecular Weight | 401.46 |
Formula | C23H23N5O2 |
CAS Number | 226954-04-7 |
Solubility (25°C) | DMSO 40.15 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years |
In solvent -80°C 6 months ; -20°C 1 month |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.