AC 55541 protease-activated receptor 2 (PAR2) agonist 916170-19-9

AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.

Product name

AC 55541, protease-activated receptor 2 (PAR2) agonist

Description

Potent, selective protease-activated receptor 2 (PAR2) agonist

Alternative names

AC-55541

AC55541

N-[[1-(3-bromo-phenyl)-eth-(E)-ylidene-hydrazinocarbonyl]-(4-oxo-3,4-dihydro-phthalazin-1-yl)-methyl]-benzamide

(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide

Biological description

Potent, selective protease-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

CAS Number

916170-19-9

Molecular weight

518.36

Molecular formula

C₂₅H₂₀BrN₅O₃

PubChem identifier

9589606

Storage instructions

Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Solubility overview

Soluble in DMSO to 50 mM

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.